DeCS Server - List Exact Term

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DeCS

Descriptor English:

Suppressor of Cytokine Signaling 3 Protein

Descriptor Spanish:

Proteína 3 Supresora de la Señalización de Citocinas

Descriptor Portuguese:

Proteína 3 Supressora da Sinalização de Citocinas

Synonyms English:

Protein, SOCS3
SOCS3 Protein
Suppressor of Cytokine Signaling Protein 3

Tree Number:

Definition English:

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.

History Note English:

2017

Allowable Qualifiers English:

Record Number:

56544

Unique Identifier:

D000071223

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DeCS